Dr. Jeffrey Noel
Jeffrey K Noel
Humboldt Foundation Fellow
Max Delbruck Center, Berlin
B.S. 2005, University of Wisconsin-Madison
Ph.D. 2012, University of California-San Diego
Postdoctoral Fellow, Rice University
Humboldt Foundation Fellow, Berlin
Molecular biophysics of biomolecular folding and function
Protein dynamics takes place on a rugged funnel-like energy landscape that is biased towards the native state. In naturally occurring proteins, this ruggedness caused by non-native interactions is sufficiently smooth (minimally frustrated) that the landscape is dominated by the native interactions. This provides the theoretical foundation for a class of minimalist protein models called structure-based models (SBMs).
As a Humboldt Fellow in Berlin, I am collaborating with Oliver Daumke and Alexander Mikhailov in an effort to provide a structure-based understanding of the dynamics and power stroke of the dynamin molecular motor.
I am also involved with extending and enhancing our SBM software framework (SMOG, http://smog-server.org).
Hayes RL, Noel JK, Mandic A, Whitford PC, Udayan M, Sanbonmatsu KY, Onuchic JN (2015) Generalized Manning Condensation Model Captures the RNA Ion Atmosphere. Phys. Rev. Lett. 114, 258105. [link]
Noel JK, Chahine J, Leite VBP, Whitford PC (2014) Capturing Transition Paths and Transition States for Conformational Rearrangements in the Ribosome. Biophys. J. 107, 2872-81. [link]
Lin X, Eddy NR, Noel JK, Whitford PC, Wang Q, Ma J, Onuchic JN (2014) Order and disorder control the functional rearrangement of influenza hemagglutinin. PNAS 111(33):12049-54. [link]
Noel JK, Onuchic JN, Sulkowska JI (2013) Knotting a protein in explicit solvent. J. Phys. Chem. Lett. 4(21) 3570-3. [link]
Page created and maintained by Jeff Noel and Paul Whitford