Dr. Jeffrey Noel

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Jeffrey K Noel


Humboldt Foundation Fellow

AG Daumke
Max Delbruck Center, Berlin
E-mail

B.S. 2005, University of Wisconsin-Madison
Ph.D. 2012, University of California-San Diego
Postdoctoral Fellow, Rice University
Currently:
Humboldt Foundation Fellow, Berlin

 

 

Molecular biophysics of biomolecular folding and function

Protein dynamics takes place on a rugged funnel-like energy landscape that is biased towards the native state. In naturally occurring proteins, this ruggedness caused by non-native interactions is sufficiently smooth (minimally frustrated) that the landscape is dominated by the native interactions. This provides the theoretical foundation for a class of minimalist protein models called structure-based models (SBMs).

As a Humboldt Fellow in Berlin, I am collaborating with Oliver Daumke and Alexander Mikhailov in an effort to provide a structure-based understanding of the dynamics and power stroke of the dynamin molecular motor.

I am also involved with extending and enhancing our SBM software framework (SMOG, http://smog-server.org).

Selected Publications:

Noel JK, Whitford PC (2016) How EF-Tu can enable efficient proofreading of aa-tRNA by the ribosome. Nature Comms. 7, 13314. [link]

Noel JK, Levi M, Raghunathan M, Lammert H, Hayes RL, Onuchic JN, Whitford PC (2016) SMOG 2: A Versatile Software Package for Generating Structure-Based Models. PLOS Comput Biol 12(3): e1004794. [link]

Noel JK, Chahine J, Leite VBP, Whitford PC (2014) Capturing Transition Paths and Transition States for Conformational Rearrangements in the Ribosome. Biophys. J. 107, 2872-81. [link]

Lin X, Eddy NR, Noel JK, Whitford PC, Wang Q, Ma J, Onuchic JN (2014) Order and disorder control the functional rearrangement of influenza hemagglutinin. PNAS 111(33):12049-54. [link]

Noel JK, Onuchic JN, Sulkowska JI (2013) Knotting a protein in explicit solvent. J. Phys. Chem. Lett. 4(21) 3570-3. [link]

Please direct questions and comments to info@smog-server.org.
Page created and maintained by Jeff Noel and Paul Whitford