Dr. Jeffrey Noel
Education
B.S. 2005, University of Wisconsin-Madison
Ph.D. 2012, University of California-San Diego
Professional Positions
Postdoctoral Fellow, Rice University, Houston TX
Humboldt Foundation Fellow, Max Delbruck Center, Berlin
Currently: Modeling Expert with RheoCube
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Molecular biophysics of biomolecular folding and function
Protein dynamics takes place on a rugged funnel-like energy landscape that is biased towards the native state. In naturally occurring proteins, this ruggedness caused by non-native interactions is sufficiently smooth (minimally frustrated) that the landscape is dominated by the native interactions. This provides the theoretical foundation for a class of minimalist protein models called structure-based models (SBMs).
Despite having recently moved my professional life to industry, I am still involved and interested in several areas of biomolecular research. In particular:
- Extending and enhancing our SBM software framework (SMOG, https://smog-server.org)
- Assembly and function of the polymeric protein filaments formed by dynamin related proteins
- Folding and function of knotted proteins
Selected Publications:
Ganichkin O, Vancraenenbroeck R, Rosenblum G, Hofmann H, Mikhailov AS, Daumke O, Noel JK (2021) Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor. Proc. Natl. Acad. Sci. USA 118, e2101144118. link]
Liu J, Alvarez FJD, Clare DK, Noel JK, and Zhang P (2021) CryoEM structure of the super-constricted two-start dynamin 1 filament. Nature Comms. (in press)
Noel JK, Noe F, Daumke O, and Mikhailov AS (2019) Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes. Biophys. J. [link]
Faelber K, Dietrich L, Noel JK, ... , Kuhlbrandt W, Daumke O (2019) Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature. [link]
Noel JK, Whitford PC (2016) How EF-Tu can enable efficient proofreading of aa-tRNA by the ribosome. Nature Comms. 7, 13314. [link]
Noel JK, Levi M, Raghunathan M, Lammert H, Hayes RL, Onuchic JN, Whitford PC (2016) SMOG 2: A Versatile Software Package for Generating Structure-Based Models. PLOS Comput Biol 12(3): e1004794. [link]
Noel JK, Onuchic JN, Sulkowska JI (2013) Knotting a protein in explicit solvent. J. Phys. Chem. Lett. 4(21) 3570-3. [link]
Page created and maintained by Jeff Noel and Paul Whitford