Dr. Jeffrey Noel


Jeffrey K Noel

Humboldt Foundation Fellow

AG Daumke
Max Delbruck Center, Berlin

B.S. 2005, University of Wisconsin-Madison
Ph.D. 2012, University of California-San Diego
Postdoctoral Fellow, Rice University
Humboldt Foundation Fellow, Berlin



Molecular biophysics of biomolecular folding and function

Protein dynamics takes place on a rugged funnel-like energy landscape that is biased towards the native state. In naturally occurring proteins, this ruggedness caused by non-native interactions is sufficiently smooth (minimally frustrated) that the landscape is dominated by the native interactions. This provides the theoretical foundation for a class of minimalist protein models called structure-based models (SBMs).

As a Humboldt Fellow in Berlin, I am collaborating with Oliver Daumke and Alexander Mikhailov in an effort to provide a structure-based understanding of the dynamics and power stroke of the dynamin molecular motor.

I am also involved with extending and enhancing our SBM software framework (SMOG, https://smog-server.org).

Selected Publications:

Noel JK, Noe F, Daumke O, and Mikhailov AS (2019) Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes. Biophys. J. [link]

Faelber K, Dietrich L, Noel JK, ... , Kuhlbrandt W, Daumke O (2019) Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature. [link]

Liu JW, Noel JK, Low, HH (2018) Structural basis for membrane tethering by a bacterial dynamin-like pair. Nature Communications, 9(1), 3345. [link]

Noel JK, Whitford PC (2016) How EF-Tu can enable efficient proofreading of aa-tRNA by the ribosome. Nature Comms. 7, 13314. [link]

Noel JK, Levi M, Raghunathan M, Lammert H, Hayes RL, Onuchic JN, Whitford PC (2016) SMOG 2: A Versatile Software Package for Generating Structure-Based Models. PLOS Comput Biol 12(3): e1004794. [link]

Noel JK, Onuchic JN, Sulkowska JI (2013) Knotting a protein in explicit solvent. J. Phys. Chem. Lett. 4(21) 3570-3. [link]

Please direct questions and comments to info@smog-server.org.
Page created and maintained by Jeff Noel and Paul Whitford